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Interactions between the APP C-terminal domain and G-proteins mediate calcium dysregulation and Aβ toxicity in Alzheimer disease
Alzheimer’s Disease (AD) is characterized by neuropathological accumulations of Amyloid-β(1–42) (Aβ(1–42)), a cleavage product of the Amyloid Precursor Protein (APP). Recent studies have highlighted the role of APP in Aβ-mediated toxicity and have implicated the G-protein system; however the exact m...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838422/ https://ncbi.nlm.nih.gov/pubmed/19368557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06997.x |
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