Mezlocillin Pharmacokinetics After Single Intravenous Doses to Patients with Varying Degrees of Renal Function

The pharmacokinetics of mezlocillin were examined after single 2- and 4-g intravenous injections to three groups of male patients with creatinine clearances of I ≥ 60, II = 21 to 59, and III ≤ 20 ml min(−1) 1.73 m(−2). The decline in serum antibiotic levels was biphasic in all groups, and serum data...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Frimodt-Möller, Niels, Maigaard, Sven, Toothaker, Roger D., Bundtzen, Robert W., Brodey, Mitchell V., Craig, William A., Welling, Peter G., Madsen, Paul O.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1980
Témata:	Pharmacology and Therapeutics
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6446877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.17.4.599
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