Targeting a Novel N-terminal Epitope of Death Receptor 5 Triggers Tumor Cell Death

Tumor necrosis factor-related apoptosis-inducing ligand receptors death receptor (DR) 4 and DR5 are potential targets for antibody-based cancer therapy. Activation of the proapoptotic DR5 in various cancer cells triggers the extrinsic and/or intrinsic pathway of apoptosis. It has been shown that the...

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Main Authors: Zhang, Peng, Zheng, Yong, Shi, Juan, Zhang, Yaxi, Liu, Shilian, Liu, Yanxin, Zheng, Dexian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838317/
https://ncbi.nlm.nih.gov/pubmed/20106985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070680
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