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Targeting a Novel N-terminal Epitope of Death Receptor 5 Triggers Tumor Cell Death
Tumor necrosis factor-related apoptosis-inducing ligand receptors death receptor (DR) 4 and DR5 are potential targets for antibody-based cancer therapy. Activation of the proapoptotic DR5 in various cancer cells triggers the extrinsic and/or intrinsic pathway of apoptosis. It has been shown that the...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838317/ https://ncbi.nlm.nih.gov/pubmed/20106985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070680 |
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