Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors: AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS

Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat angiogenesis-driven diseases, including cancer. TSP-1 regulates angiogenesis through different mechanisms, including binding and sequestration of the angiogenic factor fibrob...

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Autori principali: Colombo, Giorgio, Margosio, Barbara, Ragona, Laura, Neves, Marco, Bonifacio, Silvia, Annis, Douglas S., Stravalaci, Matteo, Tomaselli, Simona, Giavazzi, Raffaella, Rusnati, Marco, Presta, Marco, Zetta, Lucia, Mosher, Deane F., Ribatti, Domenico, Gobbi, Marco, Taraboletti, Giulia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838296/
https://ncbi.nlm.nih.gov/pubmed/20056600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085605
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