Intein-mediated Cyclization of Bacterial Acyl Carrier Protein Stabilizes Its Folded Conformation but Does Not Abolish Function

Bacterial acyl carrier protein (ACP) is essential for the synthesis of fatty acids and serves as the major acyl donor for the formation of phospholipids and other lipid products. Acyl-ACP encloses attached fatty acyl groups in a hydrophobic pocket within a four-helix bundle, but must at least partia...

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Bibliografiske detaljer
Main Authors: Volkmann, Gerrit, Murphy, Peter W., Rowland, Elden E., Cronan, John E., Liu, Xiang-Qin, Blouin, Christian, Byers, David M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838282/
https://ncbi.nlm.nih.gov/pubmed/20083605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060863
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