THERAPEUTIC TARGETING OF “DARPP-32”: A KEY SIGNALING MOLECULE IN THE DOPIMINERGIC PATHWAY FOR THE TREATMENT OF OPIATE ADDICTION

The 32-kDa dopamine- and adenosine 3′,5′-monophosphate-regulated phosphoprotein (DARPP-32) is recognized to be critical to the pathogenesis of drug addiction. Opiates via the μ-receptor act on the dopaminergic system in the brain and modulates the expression of DARPP-32 phosphoprotein which is an im...

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Detalhes bibliográficos
Main Authors: Mahajan, Supriya D., Aalinkeel, Ravikumar, Reynolds, Jessica L., Nair, Bindukumar B., Sykes, Donald E., Hu, Zihua, Bonoiu, Adela, Ding, Hong, Prasad, Paras N., Schwartz, Stanley A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838237/
https://ncbi.nlm.nih.gov/pubmed/19897079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0074-7742(09)88008-2
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