Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA

HIV-1 replication can be efficiently inhibited by intracellular expression of an siRNA targeting the viral RNA. We used a well-validated siRNA (si510) which targets the poly A/TAR (transactivator of the HIV-1 LTR) site and suppresses viral replication. Nanotechnology holds much potential for impact...

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Detalhes bibliográficos
Main Authors: Mahajan, Supriya D., Aalinkeel, Ravikumar, Reynolds, Jessica L., Nair, Bindukumar, Sykes, Donald E., Law, Wing-Cheung, Ding, Hong, Bergey, Earl J., Prasad, Paras N., Schwartz, Stanley A.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108557/
https://ncbi.nlm.nih.gov/pubmed/21660279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/719139
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