A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3(F136L)) cannot regulate erythropoietin responses

Recently several different JAK2 exon12 mutations have been identified in V617F negative polycythaemia vera (PV) or idiopathic erythrocytosis (IE) patients. The patients present with erythrocytosis, ligand-independent cell growth and low serum erythropoietin (EPO) levels. Within this group, a deletio...

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Main Authors: Suessmuth, Yvonne, Elliott, Joanne, Percy, Melanie J., Inami, Mitsuharu, Attal, Hila, Harrison, Claire N., Inokuchi, Koiti, McMullin, Mary-Frances, Johnston, James A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838228/
https://ncbi.nlm.nih.gov/pubmed/19735488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07860.x
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