Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex

Engagement of the T-cell receptor (TCR) in human primary T cells activates a cyclic AMP (cAMP)-protein kinase A (PKA)-Csk inhibitory pathway that prevents full T-cell activation in the absence of a coreceptor stimulus. Here, we demonstrate that stimulation of CD28 leads to recruitment to lipid rafts...

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Detalhes bibliográficos
Main Authors: Bjørgo, Elisa, Solheim, Silje A., Abrahamsen, Hilde, Baillie, George S., Brown, Kim M., Berge, Torunn, Okkenhaug, Klaus, Houslay, Miles D., Taskén, Kjetil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838077/
https://ncbi.nlm.nih.gov/pubmed/20086095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00696-09
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