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Traumatic Brain Injury May Increase the Risk for Frontotemporal Dementia through Reduced Progranulin

Frontotemporal lobar degeneration with TAR-DNA-binding protein inclusions (FTLD-TDP) is the most common pathological subtype of frontotemporal dementia (FTD). Mutations leading to a loss of function in the progranulin gene (PGRN) are the most common known cause of FTLD-TDP. In agreement with the pro...

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Detalhes bibliográficos
Main Authors: Jawaid, Ali, Rademakers, Rosa, Kass, Joseph S., Kalkonde, Yogeshwar, Schulz, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837889/
https://ncbi.nlm.nih.gov/pubmed/20145419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000258704
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