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Genetic Complementation Results in Augmented Autoantibody Responses to Lupus-Associated Antigens

Lupus-prone female NZM2328 mice develop high titers of anti-nuclear and anti-dsDNA autoantibodies. Despite high expression of type I IFNs, these mice do not develop autoantibodies to the small nuclear ribonucleoprotein (snRNP) complex. Thus, additional genetic factors must regulate the generation of...

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Main Authors: Sim, Davis L, Bagavant, Harini, Scindia, Yogesh M., Ge, Yan, Gaskin, Felicia, Fu, Shu Man, Deshmukh, Umesh S.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837801/
https://ncbi.nlm.nih.gov/pubmed/19667095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901207
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