Mice Over-Expressing the Myocardial Creatine Transporter Develop Progressive Heart Failure and Show Decreased Glycolytic Capacity

The metabolic phenotype of the failing heart includes a decrease in phosphocreatine and total creatine concentration [Cr], potentially contributing to contractile dysfunction. Surprisingly, in 32 week old mice over-expressing the myocardial creatine transporter (CrT-OE), we previously demonstrated t...

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Autors principals: Phillips, Darci, Hove, Michiel ten, Schneider, Jurgen E., Wu, Colin O., Sebag-Montefiore, Liam, Aponte, Angel M., Lygate, Craig A., Wallis, Julie, Clarke, Kieran, Watkins, Hugh, Balaban, Robert S., Neubauer, Stefan
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837781/
https://ncbi.nlm.nih.gov/pubmed/19913546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.10.033
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