Development of a Recombinant Tetravalent Dengue Virus Vaccine: Immunogenicity and Efficacy Studies in Mice and Monkeys

Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system. Binding of conformationally sensitive antibodies as well as x-ray crystal structural studies indicate that the recombinant 80E subunits are prope...

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Main Authors: Clements, David E., Coller, Beth-Ann G., Lieberman, Michael M., Ogata, Steven, Wang, Gordon, Harada, Kent E., Putnak, J. Robert, Ivy, John M., McDonell, Michael, Bignami, Gary S., Peters, Iain D., Leung, Julia, Weeks-Levy, Carolyn, Nakano, Eileen T., Humphreys, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837772/
https://ncbi.nlm.nih.gov/pubmed/20097152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.01.022
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