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In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine).

In vitro passage of the Patton strain of herpes simplex virus type 1 (HSV-1-P) in the presence of acycloguanosine (ACG) led to the emergence of a highly drug-resistant strain (HSV-1-P-ACG-R). Over 1% of virions in 6 of 15 HSV strains tested were able to form plaques in the presence of 10 mumol of AC...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Smith, K O, Kennell, W L, Poirier, R H, Lynd, F T
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283749/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6247967/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.17.2.144
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