In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine).

In vitro passage of the Patton strain of herpes simplex virus type 1 (HSV-1-P) in the presence of acycloguanosine (ACG) led to the emergence of a highly drug-resistant strain (HSV-1-P-ACG-R). Over 1% of virions in 6 of 15 HSV strains tested were able to form plaques in the presence of 10 mumol of AC...

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Библиографические подробности
Главные авторы: Smith, K O, Kennell, W L, Poirier, R H, Lynd, F T
Формат: Artigo
Язык:Inglês
Опубликовано: 1980
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC283749/
https://ncbi.nlm.nih.gov/pubmed/6247967
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