The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria

Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). The Met genotypes slow the metabolism of catechol oes...

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Main Authors: Ashton, Katie A, Meldrum, Cliff J, McPhillips, Mary L, Suchy, Janina, Kurzawski, Grzegorz, Lubinski, Jan, Scott, Rodney J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2006
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837292/
https://ncbi.nlm.nih.gov/pubmed/20223014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-4-2-94
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