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GF120918 as a chemical Abcg2 knockout model to study nitrofurantoin transfer into milk
Genetic knockout mice studies suggested ABCG2/Abcg2 translocates nitrofurantoin at the mammary – blood barrier resulting in drug accumulation in milk. The purpose of this study was to establish the role of Abcg2 in nitrofurantoin accumulation in rat milk using GF120918 as a “chemical knockout” equiv...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837273/ https://ncbi.nlm.nih.gov/pubmed/18799806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.021980 |
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