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Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

Forkhead box transcription factor FOXO3a, a key regulator of cell survival, is regulated by reversible phosphorylation and subcellular localization. Although the kinases regulating FOXO3a activity have been characterized, the role of protein phosphatases (PP) in the control of FOXO3a subcellular loc...

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Detalhes bibliográficos
Main Authors: Singh, Amrik, Ye, Min, Bucur, Octavian, Zhu, Shudong, Tanya Santos, Maria, Rabinovitz, Isaac, Wei, Wenyi, Gao, Daming, Hahn, William C., Khosravi-Far, Roya
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836964/
https://ncbi.nlm.nih.gov/pubmed/20110348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-09-0795
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