The miR-17/92 polycistron is up-regulated in Sonic hedgehog-driven medulloblastomas and induced by N-myc in Sonic hedgehog-treated cerebellar neural precursors

Medulloblastoma is the most common malignant pediatric brain tumour and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution SNP genotyping arrays and subs...

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Hauptverfasser: Northcott, Paul A., Fernandez-L, Africa, Hagan, John P., Ellison, David W., Grajkowska, Wesia, Gillespie, Yancey, Grundy, Richard, Van Meter, Timothy, Rutka, James T., Croce, Carlo M., Kenney, Anna Marie, Taylor, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836891/
https://ncbi.nlm.nih.gov/pubmed/19351822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4710
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