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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). Previous studies with reduction of LDHA expression indicate t...

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Detalhes bibliográficos
Main Authors: Le, Anne, Cooper, Charles R., Gouw, Arvin M., Dinavahi, Ramani, Maitra, Anirban, Deck, Lorraine M., Royer, Robert E., Vander Jagt, David L., Semenza, Gregg L., Dang, Chi V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836706/
https://ncbi.nlm.nih.gov/pubmed/20133848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914433107
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