Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

BACKGROUND: Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously examines the spectrum of both types of changes in human tumors on a genome-wide...

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Auteurs principaux: Poage, Graham M., Christensen, Brock C., Houseman, E. Andres, McClean, Michael D., Wiencke, John K., Posner, Marshall R., Clark, John R., Nelson, Heather H., Marsit, Carmen J., Kelsey, Karl T.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836370/
https://ncbi.nlm.nih.gov/pubmed/20300172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009651
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