Extracellular ubiquitin inhibits β-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3β and mitochondrial pathways

AIMS: β-Adrenergic receptor (β-AR) stimulation induces apoptosis in adult rat ventricular myocytes (ARVMs) via the activation of glycogen synthase kinase-3β (GSK-3β) and mitochondrial pathways. However, β-AR stimulation induces apoptosis only in a fraction (∼15–20%) of ARVMs. We hypothesized that AR...

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Detalhes bibliográficos
Main Authors: Singh, Mahipal, Roginskaya, Marina, Dalal, Suman, Menon, Bindu, Kaverina, Ekaterina, Boluyt, Marvin O., Singh, Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836259/
https://ncbi.nlm.nih.gov/pubmed/20015977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp402
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