The antioxidant Trolox restores mitochondrial membrane potential and Ca(2+)-stimulated ATP production in human complex I deficiency

Malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative diseases. Previous work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species (ROS) and reductions in both total Ca(2+) content of the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Distelmaier, Felix, Visch, Henk-Jan, Smeitink, Jan A. M., Mayatepek, Ertan, Koopman, Werner J. H., Willems, Peter H. G. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer-Verlag 2009
Gaiak:
Original Aricle
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836243/
https://ncbi.nlm.nih.gov/pubmed/19255735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-009-0452-5
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