Disruption of the Aortic Elastic Lamina and Medial Calcification Share Genetic Determinants in Mice

BACKGROUND: Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans. METHODS AND RESULTS: We now report evidence of shared genetic basis for disruption of the elastic lamina (medial disru...

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Main Authors: Wang, Susanna S., Martin, Lisa J., Schadt, Eric E., Meng, Haijin, Wang, Xuping, Zhao, Wei, Ingram-Drake, Leslie, Nebohacova, Martina, Mehrabian, Margarete, Drake, Thomas A., Lusis, Aldons J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836127/
https://ncbi.nlm.nih.gov/pubmed/20031637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.860270
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