Allosteric determinants in guanine nucleotide-binding proteins

Members of the G protein superfamily contain nucleotide-dependent switches that dictate the specificity of their interactions with binding partners. Using a sequence-based method termed statistical coupling analysis (SCA), we have attempted to identify the allosteric core of these proteins, the netw...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hatley, Mark E., Lockless, Steve W., Gibson, Scott K., Gilman, Alfred G., Ranganathan¶, Rama
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14623969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1835919100
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