Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I: CONSTRAINTS AND FINE-TUNING IN THE EVOLUTION OF A PROTEIN FAMILY

Proinsulin exhibits a single structure, whereas insulin-like growth factors refold as two disulfide isomers in equilibrium. Native insulin-related growth factor (IGF)-I has canonical cystines (A6—A11, A7–B7, and A20—B19) maintained by IGF-binding proteins; IGF-swap has alternative pairing (A7–A11, A...

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Autors principals: Sohma, Youhei, Hua, Qing-xin, Liu, Ming, Phillips, Nelson B., Hu, Shi-Quan, Whittaker, Jonathan, Whittaker, Linda J., Ng, Aubree, Roberts, Charles T., Arvan, Peter, Kent, Stephen B. H., Weiss, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836107/
https://ncbi.nlm.nih.gov/pubmed/19959476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.062992
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