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Mitochondrial C(1)-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos

Mitochondrial folate-dependent one-carbon (1-C) metabolism converts 1-C donors such as serine and glycine to formate, which is exported and incorporated into the cytoplasmic tetrahydrofolate (THF) 1-C pool. Developing embryos depend on this mitochondrial pathway to provide 1-C units for cytoplasmic...

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Autori principali: Pike, Schuyler T., Rajendra, Rashmi, Artzt, Karen, Appling, Dean R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836066/
https://ncbi.nlm.nih.gov/pubmed/19948730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079855
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