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Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde

Instability of repetitive sequences is a hallmark of human cancer, and its enhancement has been linked to oxidative stress. Malondialdehyde is an endogenous product of oxidative stress that reacts with guanine to form the exocyclic adduct, pyrimido[1,2- α]purin-10(3H)-one (M(1)G). We used site-speci...

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Autors principals: VanderVeen, Laurie A., Hashim, Muhammed F., Shyr, Yu, Marnett, Lawrence J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC283577/
https://ncbi.nlm.nih.gov/pubmed/14603032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2332176100
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