Feedback between p21 and reactive oxygen production is necessary for cell senescence

Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age-related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leading to establishment of senescence are proving to be more complex t...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Passos, João F, Nelson, Glyn, Wang, Chunfang, Richter, Torsten, Simillion, Cedric, Proctor, Carole J, Miwa, Satomi, Olijslagers, Sharon, Hallinan, Jennifer, Wipat, Anil, Saretzki, Gabriele, Rudolph, Karl Lenhard, Kirkwood, Tom B L, von Zglinicki, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835567/
https://ncbi.nlm.nih.gov/pubmed/20160708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.5
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky