Feedback between p21 and reactive oxygen production is necessary for cell senescence

Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age-related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leading to establishment of senescence are proving to be more complex t...

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Autors principals: Passos, João F, Nelson, Glyn, Wang, Chunfang, Richter, Torsten, Simillion, Cedric, Proctor, Carole J, Miwa, Satomi, Olijslagers, Sharon, Hallinan, Jennifer, Wipat, Anil, Saretzki, Gabriele, Rudolph, Karl Lenhard, Kirkwood, Tom B L, von Zglinicki, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835567/
https://ncbi.nlm.nih.gov/pubmed/20160708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.5
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