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Antigen-Specific Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor: Structure Optimization and Pharmacokinetics

The objective of this study was to optimize the in vivo activity of proteolipid protein (PLP)-bifunctional peptide inhibitor (BPI) molecule to suppress experimental autoimmune encephalomyelitis (EAE) in SJL/J mice and evaluate pharmacokinetic profiles of PLP-BPI. PLP-BPI is constructed via conjugati...

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Detalhes bibliográficos
Main Authors: Ridwan, Rahmawati, Kiptoo, Paul, Kobayashi, Naoki, Weir, Scott, Hughes, Michael, Williams, Todd, Soegianto, Rondang, Siahaan, Teruna J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835440/
https://ncbi.nlm.nih.gov/pubmed/20026673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.161109
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