MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection

During acute lymphocytic choriomeningitis virus (LCMV) infection, CD8 T cells rapidly expand and differentiate into effectors that are required for viral clearance. The accumulation of activated T cells is greatly reduced in mice lacking the adaptor molecule MyD88. Although MyD88 has generally been...

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Main Authors: Rahman, Adeeb H., Cui, Weiguo, LaRosa, David F., Taylor, Devon K., Zhang, Jidong, Goldstein, Daniel R., Wherry, E. John, Kaech, Susan M., Turka, Laurence A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835404/
https://ncbi.nlm.nih.gov/pubmed/18768833
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