Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa: High Stability of Collagen VII Favors Long-term Skin Integrity

Here, we report on the first systematic long-term study of fibroblast therapy in a mouse model for recessive dystrophic epidermolysis bullosa (RDEB), a severe skin-blistering disorder caused by loss-of-function of collagen VII. Intradermal injection of wild-type (WT) fibroblasts in >50 mice incre...

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Detalhes bibliográficos
Main Authors: Kern, Johannes S, Loeckermann, Stefan, Fritsch, Anja, Hausser, Ingrid, Roth, Wera, Magin, Thomas M, Mack, Claudia, Müller, Marcel L, Paul, Oliver, Ruther, Patrick, Bruckner-Tuderman, Leena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835252/
https://ncbi.nlm.nih.gov/pubmed/19568221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.144
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