Sonic Hedgehog Expands Diaphyseal Trabecular Bone Altering Bone Marrow Niche and Lymphocyte Compartment

Bone marrow contains distinct microenvironments that regulate hematopoietic stem cells (HSCs). The endosteal HSC niche includes osteoblasts, mineral, and extracellular matrix proteins that interact through various molecular signals to control HSCs. Sonic hedgehog (Shh) is a morphogen involved in the...

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Bibliographic Details
Main Authors: Kiuru, Maija, Hidaka, Chisa, Hubner, Ralf-Harto, Solomon, Jason, Krause, Anja, Leopold, Philip L, Crystal, Ronald G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835226/
https://ncbi.nlm.nih.gov/pubmed/19436267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.102
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