Host and Vector-dependent Effects on the Risk of Germline Transmission of AAV Vectors

The assessment of the risk of germline transmission of vector-coded sequences is critical for clinical translation of gene transfer strategies. We used rabbit models to analyze the risk of germline transmission of adeno-associated viral (AAV) vectors. Intravenous injection of AAV-2 or AAV-8 resulted...

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Detalhes bibliográficos
Main Authors: Favaro, Patricia, Downey, Harre D, Zhou, J Shangzhen, Wright, J Fraser, Hauck, Bernd, Mingozzi, Federico, High, Katherine A, Arruda, Valder R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835193/
https://ncbi.nlm.nih.gov/pubmed/19293773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.56
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