Induction of Immune Tolerance to FIX Following Muscular AAV Gene Transfer Is AAV-dose/FIX-level Dependent

Direct intramuscular injection (IM) of adeno-associated virus (AAV) has been proven a safe and potentially efficient procedure for gene therapy of many genetic diseases including hemophilia B. It is, however, contentious whether high antigen level induces tolerance or immunity to coagulation factor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kelly, Meagan E, Zhuo, Jiacai, Bharadwaj, Arpita S, Chao, Hengjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835131/
https://ncbi.nlm.nih.gov/pubmed/19240690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.25
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados