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Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cells
The nature of viral vectors is suggested to be a significant contributor to undesirable immune responses subsequent to gene transfer. Such viral vectors, recognized as danger signals by the host immune system, activate dendritic cells (DCs), causing unwanted antivector and/or transgene product immun...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810988/ https://ncbi.nlm.nih.gov/pubmed/19965663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-239509 |
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