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ICP0 Inhibits the Decrease of HSV Amplicon-mediated Transgene Expression
The herpes simplex virus (HSV) amplicon vector produces an initial host response that limits transgene expression. In this study, we hypothesized that restoration of the HSV gene infected cell protein (ICP0) into the amplicon could circumvent this host response and thus overcome silencing of encoded...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835108/ https://ncbi.nlm.nih.gov/pubmed/19223864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.306 |
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