ICP0 Inhibits the Decrease of HSV Amplicon-mediated Transgene Expression

The herpes simplex virus (HSV) amplicon vector produces an initial host response that limits transgene expression. In this study, we hypothesized that restoration of the HSV gene infected cell protein (ICP0) into the amplicon could circumvent this host response and thus overcome silencing of encoded...

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Bibliografiske detaljer
Main Authors: Suzuki, Masataka, Kasai, Kazue, Ohtsuki, Akihiro, Godlewski, Jakub, Nowicki, Michal O, Chiocca, E Antonio, Saeki, Yoshinaga
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835108/
https://ncbi.nlm.nih.gov/pubmed/19223864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.306
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