Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

Helper-dependent adenoviral vectors (HDAd) are devoid of all viral coding sequences and are thus an improvement over early generation Ad because they can provide long-term transgene expression in vivo without chronic toxicity. However, high vector doses are required to achieve efficient hepatic tran...

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Autors principals: Brunetti-Pierri, Nicola, Stapleton, Gary E, Law, Mark, Breinholt, John, Palmer, Donna J, Zuo, Yu, Grove, Nathan C, Finegold, Milton J, Rice, Karen, Beaudet, Arthur L, Mullins, Charles E, Ng, Philip
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835071/
https://ncbi.nlm.nih.gov/pubmed/19050700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.257
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