Mechanisms for glycolipid antigen-driven cytokine polarization by Vα14i NKT cells

Certain glycolipid antigens (Ags) for Vα14i NKT cells can direct the overall cytokine balance of the immune response. T(H)2-biasing OCH has a lower TCR avidity than the most potent agonist known, αGalCer. Although the CD1d-exposed portions of OCH and αGalCer are identical, structural analysis indica...

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Autori principali: Sullivan, Barbara A., Nagarajan, Niranjana A., Wingender, Gerhard, Wang, Jing, Scott, Iain, Tsuji, Moriya, Franck, Richard W., Porcelli, Steven, Zajonc, Dirk, Kronenberg, Mitchell
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834884/
https://ncbi.nlm.nih.gov/pubmed/19949076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902880
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