Parp1 activation in mouse embryonic fibroblasts promotes Pol β-dependent cellular hypersensitivity to alkylation damage

Alkylating agents induce cell death in wild-type (WT) mouse embryonic fibroblasts (MEFs) by multiple mechanisms, including apoptosis, autophagy and necrosis. DNA polymerase β (Pol β) knockout (KO) MEFs are hypersensitive to the cytotoxic effect of alkylating agents, as compared to WT MEFs. To test t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jelezcova, Elena, Trivedi, Ram N., Wang, Xiao-hong, Tang, Jiang-bo, Brown, Ashley R., Goellner, Eva M., Schamus, Sandy, Fornsaglio, Jamie L., Sobol, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834876/
https://ncbi.nlm.nih.gov/pubmed/20096707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2010.01.016
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares