Parp1 activation in mouse embryonic fibroblasts promotes Pol β-dependent cellular hypersensitivity to alkylation damage

Alkylating agents induce cell death in wild-type (WT) mouse embryonic fibroblasts (MEFs) by multiple mechanisms, including apoptosis, autophagy and necrosis. DNA polymerase β (Pol β) knockout (KO) MEFs are hypersensitive to the cytotoxic effect of alkylating agents, as compared to WT MEFs. To test t...

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Main Authors: Jelezcova, Elena, Trivedi, Ram N., Wang, Xiao-hong, Tang, Jiang-bo, Brown, Ashley R., Goellner, Eva M., Schamus, Sandy, Fornsaglio, Jamie L., Sobol, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834876/
https://ncbi.nlm.nih.gov/pubmed/20096707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2010.01.016
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