Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C(1)

BACKGROUND: Disorazoles are polyene macrodiolides isolated from a myxobacterium fermentation broth. Disorazole C(1 )was newly synthesized and found to depolymerize microtubules and cause mitotic arrest. Here we examined the cellular responses to disorazole C(1 )in both non-cancer and cancer cells an...

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Hlavní autoři: Xu, Fengfeng L, Rbaibi, Youssef, Kiselyov, Kirill, Lazo, John S, Wipf, Peter, Saunders, William S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834648/
https://ncbi.nlm.nih.gov/pubmed/20181182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-10-1
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