Toward gene therapy of premature ovarian failure: intraovarian injection of adenovirus expressing human FSH receptor restores folliculogenesis in FSHR(−/−) FORKO mice

A homozygous missense mutation, C566T, in the follicle stimulation hormone receptor (FSHR) gene has been linked to premature ovarian failure. The disease leads to infertility in a normal karyotype female with an elevated follicle stimulating hormone (FSH) and decreased serum estrogen level. Female m...

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Main Authors: Ghadami, M., El-Demerdash, E., Salama, S.A., Binhazim, A.A., Archibong, A.E., Chen, X., Ballard, B.R., Sairam, M.R., Al-Hendy, A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834408/
https://ncbi.nlm.nih.gov/pubmed/20086006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaq003
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