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Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-κB pathway

The oncogenic potential of the HTLV-1 Tax protein involves activation of the NF-κB pathway, which depends on Tax phosphorylation, ubiquitination and sumoylation. We demonstrate that the nuclei of Tax-expressing cells, including HTLV-1 transformed T-lymphocytes, contain a pool of Tax molecules acetyl...

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Bibliografiske detaljer
Main Authors: Lodewick, Julie, Lamsoul, Isabelle, Polania, Angela, Lebrun, Sylvie, Burny, Arsène, Ratner, Lee, Bex, Françoise
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834172/
https://ncbi.nlm.nih.gov/pubmed/19200568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.12.043
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