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The nucleocapsid protein specifically anneals tRNA(Lys-3) onto a noncomplementary primer binding site within the HIV-1 RNA genome in vitro
HIV type 1 (HIV-1) specifically uses host cell tRNA(Lys-3 )as a primer for reverse transcription. The 3′ 18 nucleotides of this tRNA are complementary to a region on the HIV RNA genome known as the primer binding site (PBS). HIV-1 has a strong preference for maintaining a lysine-specific PBS in vivo...
Gardado en:
| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC28340/ https://ncbi.nlm.nih.gov/pubmed/9391060 |
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