The nucleocapsid protein specifically anneals tRNA(Lys-3) onto a noncomplementary primer binding site within the HIV-1 RNA genome in vitro
HIV type 1 (HIV-1) specifically uses host cell tRNA(Lys-3 )as a primer for reverse transcription. The 3′ 18 nucleotides of this tRNA are complementary to a region on the HIV RNA genome known as the primer binding site (PBS). HIV-1 has a strong preference for maintaining a lysine-specific PBS in vivo...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1997
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13530 |
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