Evidence for Transfer of Enzyme Product as the Basis of Metabolic Cooperation between Tissue Culture Fibroblasts of Lesch-Nyhan Disease and Normal Cells

Tissue culture fibroblasts derived from patients with Lesch-Nyhan disease (congenital hyperuricosuria) have a reduced IMP:pyrophosphate phosphoribosyltransferase (EC 2.4.2.8) activity and therefore incorporate, as detected by radioautography, much smaller amounts of tritiated hypoxanthine or guanine...

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Bibliographic Details
Main Authors: Cox, Rody P., Krauss, Marjorie R., Balis, M. Earl, Dancis, Joseph
Format: Artigo
Language:Inglês
Published: 1970
Subjects:
Biological Sciences: Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC283392/
https://ncbi.nlm.nih.gov/pubmed/5274481
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