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Evidence for Transfer of Enzyme Product as the Basis of Metabolic Cooperation between Tissue Culture Fibroblasts of Lesch-Nyhan Disease and Normal Cells

Tissue culture fibroblasts derived from patients with Lesch-Nyhan disease (congenital hyperuricosuria) have a reduced IMP:pyrophosphate phosphoribosyltransferase (EC 2.4.2.8) activity and therefore incorporate, as detected by radioautography, much smaller amounts of tritiated hypoxanthine or guanine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cox, Rody P., Krauss, Marjorie R., Balis, M. Earl, Dancis, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1970
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC283392/
https://ncbi.nlm.nih.gov/pubmed/5274481
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