Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis

Míreanna Comhchosúla

• Local IL-17 gene therapy accelerates collagen arthritis with severe bone erosion and rank ligand and rank expression in synovial infiltrate and at bone erosion sites
  le: Lubberts, E, et al.
  Foilsithe: (2001)
• Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis
  le: Lubberts, E, et al.
  Foilsithe: (2004)
• Neutralizing IL-17 during re-activation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1
  le: Koenders, MI, et al.
  Foilsithe: (2005)
• IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
  le: Koenders, MI, et al.
  Foilsithe: (2004)
• IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα
  le: Joosten, LAB, et al.
  Foilsithe: (2002)