Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis

Eitemau Tebyg

• Local IL-17 gene therapy accelerates collagen arthritis with severe bone erosion and rank ligand and rank expression in synovial infiltrate and at bone erosion sites
  gan: Lubberts, E, et al.
  Cyhoeddwyd: (2001)
• Neutralizing IL-17 during re-activation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1
  gan: Koenders, MI, et al.
  Cyhoeddwyd: (2005)
• Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis
  gan: Lubberts, E, et al.
  Cyhoeddwyd: (2004)
• Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
  gan: Joosten, LAB, et al.
  Cyhoeddwyd: (2005)
• IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
  gan: Koenders, MI, et al.
  Cyhoeddwyd: (2004)