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Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation

Glucocorticoids exert multiple anti-inflammatory activities, one of which is the inhibition of transcription dependent on the nuclear factor (NF)-κB. It has been suggested that the effect of dexamethasone (DEX), a glucocorticoid analog, is attributed to an increased production of the inhibitory IκB...

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Detalhes bibliográficos
Main Authors: De Bosscher, Karolien, Schmitz, M. Lienhard, Vanden Berghe, Wim, Plaisance, Stéphane, Fiers, Walter, Haegeman, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC28335/
https://ncbi.nlm.nih.gov/pubmed/9391055
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